Abstract
The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.
MeSH terms
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Animals
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Cardiovascular System / growth & development
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Cardiovascular System / metabolism
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Cell Differentiation
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Central Nervous System / growth & development
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Central Nervous System / metabolism
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / metabolism
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Endoderm / cytology
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Endoderm / growth & development
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Endoderm / metabolism*
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Epithelial Cells / cytology
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Epithelial Cells / metabolism
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GATA Transcription Factors / genetics*
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GATA Transcription Factors / metabolism
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Gene Expression Regulation, Developmental*
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Hematopoietic System / growth & development
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Hematopoietic System / metabolism
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Humans
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Mesoderm / cytology
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Mesoderm / growth & development
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Mesoderm / metabolism*
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Mutation
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Porphyria, Erythropoietic / genetics
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Porphyria, Erythropoietic / metabolism
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Porphyria, Erythropoietic / pathology
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Signal Transduction
Substances
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GATA Transcription Factors