PAPS PapersLong-term outcomes and the quality of life of Hirschsprung disease in adolescents who have reached 18 years or older—a 47-year single-institute experience
Section snippets
Methods
From 1963 to 2009, 184 patients with Hirschsprung disease underwent definitive surgery mostly Z-shaped anastomosis4 at Kyushu University Hospital. As a result, 146 (95.4%) of 153 patients survived and reached 17 years of age. Five cases died of early postoperative complications, such as peritonitis, enterocolitis, and pneumonia, and 2 patients died in traffic accidents 13 and 17 years after operation, respectively. Their present status and symptoms, anorectal functions, genitourinary functions,
Background of patients
The 43 patients included 35 males and 7 females. The extent of aganglionosis and the number of patients affected were as follows: lower rectum, aganglionosis restricted to the lower rectum under peritoneal reflection (n = 2); sigmoid colon, aganglionosis extended to the sigmoid colon (n = 32); left-right colon, aganglionosis extended beyond the sigmoid colon, but did not reach the cecum (n = 4); total colon, aganglionosis was limited to the total colon and 30 cm of the terminal ileum (n = 3);
Discussion
Hirschsprung disease is one of the representative functional disorders in pediatric surgery and has been considered to be curable by anastomosis of the normal ganglionic intestine to the anal canal by means of definitive surgery.
In this study, we demonstrated the functional prognosis of Hirschsprung disease in adolescents. The bowel function of postoperative state in Hirschsprung disease in adolescents who reached 18 years or older was satisfactory. Regarding the social performance, they had
Acknowledgment
We thank Mr Brian Quinn for comments and help with the manuscript. This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science and Kyushu University Interdisciplinary Programs in Education and Projects in Research Development (P&P).
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