Table 2

A summary of the studies using the rabbit model

AuthorTitleNEC protocolGestational age (days)Area of study
Gupta et al37Occurrence of necrotizing enterocolitis may be dependent on patterns of bacterial adherence and intestinal colonization: studies in caco-2 tissue culture and weanling rabbit modelAdherent E. coli isolates, from necrotizing enterocolitis cases, were able to cause pathologic changes typical of necrotizing enterocolitis in a weanling rabbit ileal loop modelNo age specificationThe role of intestinal microbial ecology in the pathophysiology of necrotizing enterocolitis
Garston et al38The role of intraluminal tension and pH in the development of necrotizing enterocolitis: an animal modelA closed intestinal loop, 20 cm distal to the cecum was created. A solution containing faty acids at pH 3 or 5 were infused into the loop at a pressure of 10 or 40 mm Hg6- to 8- weeks oldRelative effects of pH and intraluminal tension on colonic mucosa
Bozeman et al21An animal model of necrotizing enterocolitis in preterm rabbitsPups were intestinally blocked to stimulate abdominal distention. Pups were then bolus fed 120 kcal/kg/day with kitten milk replacer mixed with Enterobacter cloacae2 days prematureDeveloping a non-invasive, premature animal model that closely mimics clinical conditions
Mark et al24Super oxide dismutase prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitisTransmural injection of intestinal loops with an acidified solution of casein and calcium gluconate, mimicking the luminal milieu of afflicted neonatesNo age specificationLocalizing eicosanoids released from necrotic and healthy intestine in response to proinflammatory agents
Hwa-Young et al39Bowel sonography in sepsis with pathological correlation: an experimental studyAnimals received 1 mg/kg of E. coli O55-B5 lipopolysaccharide to induce sepsis. Bowel wall thickness and injury were evaluated.1-week oldFacilitating early detection of intestinal injury in septic infants with necrotizing enterocolitis
Erdener et al40Pentoxifylline does not prevent hypoxia/ reoxygenation-induced necrotizing enterocolitisPups were pretreated with pentoxifylline 15 min prior to being exposed to 5 min hypoxic/ reoxygenation episodes 3 times a day for 3 days1-day oldInvestigating the protective effects of pentoxifylline in necrotizing enterocolitis