PT  - JOURNAL ARTICLE
AU  - Jiajun Xu
AU  - Yangfan Tian
AU  - Jinhua Wang
AU  - Weize Xu
AU  - Zhuo Shi
AU  - Jianzhong Fu
AU  - Qiang Shu
TI  - CT quantification of ventricular volumetric parameters based on semiautomatic 3D threshold-based segmentation in porcine heart and children with tetralogy of Fallot: accuracy and feasibility
AID  - 10.1136/wjps-2019-000073
DP  - 2019 Oct 01
TA  - World Journal of Pediatric Surgery
PG  - e000073
VI  - 2
IP  - 3
4099  - http://wjps.bmj.com/content/2/3/e000073.short
4100  - http://wjps.bmj.com/content/2/3/e000073.full
SO  - World Jnl Ped Surgery2019 Oct 01; 2
AB  - Background To investigate the accuracy and feasibility of CT in quantification of ventricular volume based on semiautomatic three-dimensional (3D) threshold-based segmentation in porcine heart and children with tetralogy of Fallot (TOF).Methods Eight porcine hearts were used in the study. The atria were resected and both ventricles of the eight porcine hearts were filled with solidifiable silica gel and performed CT scanning. The water displacement volume of silica gel casting mould was referred as gold standard of ventricular volume. Results of left and right ventricular volumes measured by CT were compared with reference standard. Twenty-three children diagnosed with TOF were retrospectively included. The ventricular volumetric parameters were assessed by cardiac CT before and 6 months after surgery.Results Left ventricular and right ventricular volumes of porcine hearts measured by CT were highly correlated to casting mould (r=0.845, p=0.008; r=0.933, p=0.001), and there were no statistically significant differences (t=−1.059, p=0.325; t=−1.121, p=0.299). In children with TOF, right ventricular end-systole volumes 6 months after operation were higher than that before surgery, 21.93±4.44 vs 19.80±4.52 mL/m2, p=0.001. Right ventricular ejection fractions 6 months after surgery were lower compared with that before surgery 59.79%±4.26% vs 63.05%±5.04%, p=0.000.Conclusions CT is able to accurately assess ventricular volumetric parameters based on semiautomatic 3D threshold-based segmentation. Both of the right and left ventricular volumetric parameters could be evaluated by CT in children with TOF.