RT Journal Article
SR Electronic
T1 Treatment efficacy of tolterodine versus belladonna mixture in children with idiopathic overactive bladder
JF World Journal of Pediatric Surgery
JO World Jnl Ped Surgery
FD BMJ Publishing Group Ltd
SP e000046
DO 10.1136/wjps-2019-000046
VO 2
IS 2
A1 Zheming Xu
A1 Dehua Wu
A1 Chang Tao
A1 Juan Zhou
A1 Zhihui Zheng
A1 Daxing Tang
YR 2019
UL http://wjps.bmj.com/content/2/2/e000046.abstract
AB Objectives Children with symptoms of urinary urgency, frequency and incontinence are common in the clinic. The aim of the present study was to compare the tolerability and efficacy of tolterodine, a bladder-selective muscarinic receptor antagonist, with belladonna mixture, a traditional anticholinergic drug, in the treatment of idiopathic overactive bladder in children.Methods Children aged 5–10 years with a history of diurnal urgency, frequency and incontinence were randomly divided into two groups. Participants in group 1 were given tolterodine 1 mg twice a day for 14 days. If the results were found to be mildly ineffective, after the first 14 days of therapy, prolonged course with 2 mg twice a day was given. In group 2, the children were treated with belladonna mixture 5 mL twice a day for 14 days. Anticholinergic side effects were recorded during the therapy and efficacy was evaluated with voiding diary recorded by the parents at the beginning and end of therapy.Results A total of 668 cases were included in this study and 334 for each 25 group (496 boys and 172 girls). Evident anticholinergic side effects which could cease the therapy, such as dry mouth, constipation, mood changes, irritability, and so on, exhibited only on 2% of participants in the tolterodine group but 69% in the belladonna mixture group (p≤0.05). The symptoms of detrusor overactivity disappeared or significantly improved in 80% of children in the tolterodine group and 37% in the belladonna mixture (p≤0.05) group.Conclusions Tolterodine had better tolerability and efficacy than belladonna mixture in treating overactive bladder in children.