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Targeting autophagy in neuroblastoma
  1. Siqi Huang and
  2. Song Gu
  1. Department of Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University, Shanghai, China
  1. Correspondence to Dr Song Gu; gusong{at}shsmu.edu.cn

Abstract

Background Neuroblastoma (NB) is the most common extracellular solid tumor among children accounting for serious mortality. Macroautophagy, a common housekeeping mechanism to maintain cellular homeostasis in eukaryotic cells, is involved in tumorigenesis and chemoresistance in a spectrum of cancers.

Data resources Based on the terms of ‘autophagy’ and ‘neuroblastoma’, all the recent literature was searched and reviewed through PubMed.

Results Autophagy is associated with apoptosis, histone modifications, angiogenesis, metabolism in NB. With those facts we assume that NB is an autophagy-dependent tumor, which means that autophagy inhibition therapy is desirable.

Conclusion Autophagy in NB is pro-oncogenic, so inhibiting autophagy in high-risk NB may benefit treatment outcomes.

  • pediatrics
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This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors HSQ performed the literature review, construction and editing of the manuscript. GS gave the concept of the manuscript.

  • Funding Project of Shanghai Science and Technology Committee, grant numbers: 7441903200, 17411950402.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Not required for this review article.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data availability statement Data sharing not applicable as no data sets were generated and/or analyzed for this study. All data used in this review are available in a public, open access repository.

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