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CT quantification of ventricular volumetric parameters based on semiautomatic 3D threshold-based segmentation in porcine heart and children with tetralogy of Fallot: accuracy and feasibility
  1. Jiajun Xu1,2,
  2. Yangfan Tian1,
  3. Jinhua Wang1,
  4. Weize Xu2,
  5. Zhuo Shi1,
  6. Jianzhong Fu2 and
  7. Qiang Shu1
  1. 1Heart Center, Zhejiang University School of Medicine Children's Hospital, Hangzhou, China
  2. 2Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, Zhejiang University School of Mechanical Engineering, Hangzhou, China
  1. Correspondence to Dr Qiang Shu; shuqiang{at}


Background To investigate the accuracy and feasibility of CT in quantification of ventricular volume based on semiautomatic three-dimensional (3D) threshold-based segmentation in porcine heart and children with tetralogy of Fallot (TOF).

Methods Eight porcine hearts were used in the study. The atria were resected and both ventricles of the eight porcine hearts were filled with solidifiable silica gel and performed CT scanning. The water displacement volume of silica gel casting mould was referred as gold standard of ventricular volume. Results of left and right ventricular volumes measured by CT were compared with reference standard. Twenty-three children diagnosed with TOF were retrospectively included. The ventricular volumetric parameters were assessed by cardiac CT before and 6 months after surgery.

Results Left ventricular and right ventricular volumes of porcine hearts measured by CT were highly correlated to casting mould (r=0.845, p=0.008; r=0.933, p=0.001), and there were no statistically significant differences (t=−1.059, p=0.325; t=−1.121, p=0.299). In children with TOF, right ventricular end-systole volumes 6 months after operation were higher than that before surgery, 21.93±4.44 vs 19.80±4.52 mL/m2, p=0.001. Right ventricular ejection fractions 6 months after surgery were lower compared with that before surgery 59.79%±4.26% vs 63.05%±5.04%, p=0.000.

Conclusions CT is able to accurately assess ventricular volumetric parameters based on semiautomatic 3D threshold-based segmentation. Both of the right and left ventricular volumetric parameters could be evaluated by CT in children with TOF.

  • cardiac surgery
  • congenital abnorm
  • imaging

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  • Contributors Conception and design: JX, JW. Administrative support: QS, JF. Provision of study materials or patients: JW, WX, ZS. Collection and assembly of data: JX. Data analysis and interpretation: JX. Manuscript writing: all authors. Final approval of manuscript: all authors.

  • Funding This study was funded by Science Technology Department of Zhejiang Province of China (grant number: 2016C54006).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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