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Review
Current treatment for Wilms tumor: COG and SIOP standards
  1. Jinhu Wang1,
  2. Minju Li1,
  3. Daxing Tang1,
  4. Weizhong Gu2,
  5. Junqing Mao1 and
  6. Qiang Shu1
  1. 1Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
  2. 2Department of Pathology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
  1. Correspondence to Dr Minju Li; wjpch2{at}zju.edu.cn

Abstract

Background Wilms tumor (WT) is the most common renal malignant tumor in children. It occurs primarily at preschool age. The purpose of this review is to present current standards of diagnosis and treatment of WT around the world.

Data sources All the recent literature on diagnosis and treatment of WT were searched and reviewed.

Results Most cases with WT are sporadic. The current survival in patients with WT is high (90%). Involvement of mutidisciplinary collaborative groups in the diagnosis and treatment of WT. National Wilms Tumor Study Group (NWTSG)/Children’s Oncology Group (COG) and The International Society of Paediatric Oncology (SIOP) are two major guidelines used for the current management of WT worldwide. The major difference exists in the two guidelines is the timing of surgery: SIOP recommends using preoperative chemotherapy, and NWTSG/COG prefers using primary surgery before any adjuvant treatments.

Conclusions Most patients with WT have good overall survival outcomes. Further studies should be highlighted on how to use chemotherapy and radiotherapy under more accurate risk-stratified strategies. Surgeons must be more focusing on how to maximize preoperative and postoperative treatment possibilities for achieving optimal results of patients with WT.

  • wilms tumor
  • nephroblastoma
  • children
  • pathology
  • chemotherapy
  • surgery
  • radiotherapy

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/wjps-2019-000038

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    Footnotes

    • Contributors MJL proposed the study, wrote the first draft and is responsible for the overall content as guarantor. WJ contributed to the planning of the work described in the article. DXT, WZG, JQM and QS contributed to the design and interpretation of the study and further drafts.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement No data are available.